Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023)
نویسندگان
چکیده
Allosteric Activation of Transglutaminase 2 (TGM2) serves as a cellular target small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy-induced osteoporosis. Forskolin binds TGM2 on previously undisclosed allosteric site activate by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be found in article number 2206533 Ke-Wu Zeng co-workers.
منابع مشابه
Masthead: (Adv. Sci. 2/2016)
Open Access and Copyright: All articles published by Advanced Science are fully open access: immediately freely available to read, download and share. All articles are published under the terms of the Creative Commons Attribution License (CC-BY). The CC-BY license permits use, distribution and reproduction in any medium, provided the original work is properly cited and allows the commercial use...
متن کاملMasthead: (Adv. Sci. 2/2017)
Open Access and Copyright: All articles published by Advanced Science are fully open access: immediately freely available to read, download and share. All articles are published under the terms of the Creative Commons Attribution License (CC-BY). The CC-BY license permits use, distribution and reproduction in any medium, provided the original work is properly cited and allows the commercial use...
متن کاملContents: (Adv. Sci. 2/2017)
In article number 1600394, Almira Kurbangalieva, Katsunori Tanaka, and co-workers at the RIKEN Biofunctional Synthetic Chemistry Laboratory develop a way to engineer glycan complexes— heterogeneous clusters of sugar chains attached to proteins or lipids—in a way that allows the molecules to be transported preferentially to specific organs of the body through pattern recognition mechanisms, depe...
متن کاملMasthead: (Adv. Sci. 1‐2/2015)
Open Access and Copyright: All articles published by Advanced Science are fully open access: immediately freely available to read, download and share. All articles are published under the terms of the Creative Commons Attribution License (CC-BY). The CC-BY license permits use, distribution and reproduction in any medium, provided the original work is properly cited and allows the commercial use...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2023
ISSN: ['2198-3844']
DOI: https://doi.org/10.1002/advs.202370117